Kwesi Nyantakyi was born in Wa, in the Upper West Region of Ghana on 28 October 1968 and took to the game at an early age, rising to become a fine player, christened as "Wa Polo".

An alumnus of the University of Ghana, he studied law and passed out successfully, leading to a career, first as a state prosecutor before taking up private legal practice.

He worked with in the financial sector, with a Bank in the country and rose to become the legal manager.

Alongside his official duties, he took up football administration and served as a Vice Chairman of the Ghana League Clubs Association. He was voted as the Vice Chairman of the Ghana Football Association.

After helping implement structural reforms in the administration and governance system of the GFA, Kwesi Nyantakyi put himself up for elections in 2005 and was selected by the football family to lead the Association following a landslide victory.

He has held onto the position since after being retained twice in office. He is a member of the  Confederation of African Football's Executive Committee, a member of FIFA's Associations Committee that deals with relations between FIFA and its Members and draw up proposals for optimum cooperation.

The committee also monitors the evolution of the Statutes and regulations of FIFA, the Confederations and Members.

Kwesi Nyantakyi is also the President of the WAFU Zone B bloc.

He contributes to social programmes which includes his role on the Board of Trustees of the Sweden Ghana Medical Center (SGMC). The SGMC supports the treatment and awareness of cancer, which is fast becoming the number one killer disease in Ghana.