Two premier league sides, Wa All Stars and Medeama face an uphill task navigating their way into the MTN FA Cup Round of 32 stages.
Both sides will be in action on Sunday against Division One sides in their outstanding second round fixtures.
Upper East United, who are in good form in Zone 1 A in the Division One League will clash with rivals, All Stars at the Bolga Town Park.
And the clash between both sides has a history behind it after All Stars edged Upper East, then know as Catholic Stars to premier league promotion five years ago.
For players of Upper East United, it's revenge and nothing else as a third round tie with Pure Joy remains on the cards for the winner of the tie in Bolga.
Medeama have endured a difficult week following their derby defeat at the Tarkwa T&A Park last weekend.
But Bashir Hayford's attempt to lift themselves in a friendly in midweek ended up in defeat to Tarkwa United ahead of their FA Cup meeting with Westlandes on Sunday.
Outstanding Round of 64 fixtures
Upper East United vs Wa All Stars - 18 March
Medeama vs Westlandes - 18 March