Goran Stevanovic hands Emmanuel Bafour and Dominic Oduro debut starts in the friendly against Chile.
Both players lead the line for Ghana at the PPL Park in Philadelphia.
The game isGhana's first since their semi-final exit at the 2012 Africa Cup of Nations .
Ghana line up
Adam Kwarasey, John Paintsil, Masahudu Alhassan, John Boye, Jonathan Mensah, Anthony Annan, Derek Boateng, Kwadwo Asamoah, Sulley Muntari, Dominic Oduro, Emmanuel Baffour.
Subs: Daniel Opare, Lee Addy, Afriyie Acquah, Ricahrd Mpong, Patrick Nyarko, Abdul Warris, Daniel Agyei