Five players get to make their Africa Cup of Nations debut after being named in Ghana's starting line up to face DR Congo in Group B on Sunday.
Kick off is at 15:00 (17:00GMT).
Goalkeeper Fatau Dauda, Jerry Akaminko, Mubarak Wakaso, Albert Adomah and Christian Atsu all start for the Black Stars at the Nelson Mandela Bay Stadium in Port Elizabeth.
Kwadwo Asamoah will continue at left-back for Ghana as Akaminko partners John Boye in central defence.
Captain Asamoah Gyan leads the line for Ghana.
Ghana line up: Fatau Dauda, John Paintsil, Kwadwo Asamoah, John Boye, Jerry Akaminko, Derek Boateng, Albert Adomah, Agyemang Badu, Asamoah Gyan, Mubarak Wakasu, Christian Atsu.