Asante Kotoko, still smarting from their derby defeat in midweek play bottom side, Real Tamale United in their last outstanding match in the Glo Premier League on Saturday.
The fixture at the Len Clay Stadium in Obuasi will be Kotoko's second in four days as they juggle continental football with the domestic competition.
However, after their loss in the Kumasi derby to King Faisal, their game with the bottom side might look as an opportunity for the Porcupine Warriors to redeem themselves.
Kotoko will be expected to prey on an RTU side mired in trouble.
Handed a lengthy home ban for crowd troubles, RTU have moved round many grounds this season but their performances has been terrible as they sit at the foot of the table and winless after 17 matches in the League.
They have only five points, scored twelve times and have let in 34 goals.
For RTU, who are 22 points behind their opponents, their clash against Kotoko might be the best moment to revive their failing campaign.