Heart of Lions are the first premier league side to kick in the Round of 64 of the MTN FA Cup when they play Yagbon Stars.
Ten games will come off Thursday as the premiership campaigners travel to the Berekum Golden City.
A number of former elite sides will also be in action as King Faisal, Okwawu United and Hasaacas all push to advance to the third round of the competition.
Thursday, January 19 fixtures for Round of 64
Dunkwa Utd vrs Liberty Youth FC
King Faisal vrs Rainbow FC
Yagbon Stars vs Heart of Lions
Pure Joy vs Soccer Legends
K Dom FC vs Elmina Sharks
Dormaa Kyenkyenkye vs Okwawu United
Kfc Samosa vs Fcm Maamobi
Bazooka FC vs Tarkwa United
Hasaacas vs Bolga All Stars
Inter Allies vs Berlin FC