Medeama's first continental foray begins with away fixture in the preliminary stage of the CAF Confederation Cup.

The FA Cup winners will take the trip to Equatorial Guinea where they will take on Panther’s in the two-leg knockout following Monday's draw.

The first leg will be played in Malabo on the weekend of February 7-9, 2014.

Medeama will host the return clash at the Essipong Stadium in Sekondi on the weekend of February 14-16, 2014.

Forty-two (42) clubs will be involved in the preliminary round to be joined by ASEC Mimosas (Cote d’Ivoire), Ismaily (Egypt), Wadi Degla (Egypt), Djoliba (Mali), MAS (Morocco), Bayelsa United (Nigeria), Warri Wolves (Nigeria), El Ahly Shandy (Sudan), Etoile du Sahel (Tunisia) Club Athletic Bizertin (Tunisia) and Zesco United (Zambia) at the 1/16th round.