After two successive defeats, Medeama need a result against Liberty Professionals to halt their slide down the league table on Wednesday.
The Mauves will be at home to Liberty at the T&A Park in their third outstanding fixture in the Premier League.
Coach Roberto Paullete's side started the new campaign full of confidence after winning the club's first FA Cup. But that optimism has faded after a disappointing run following their elimination from the CAF Confederation Cup, FA Cup and two straight defeats in the league.
Defeats to Aduana Stars and AshantiGold has plunged the former FA Cup holders into the relegation zone as their chances of staying above the drop remains in doubt.
Liberty, three points above the drop also need a win to salvage their campaign as the competition heads into its final weeks.