With the World Cup qualifiers on the continent having rounded up, teams in the Glo Premier League turn their attention back to the pursuit of points.
The midweek programme has seven matches on the fixture list following the postponement of the Heart of Lions v Tema Youth match.
While the World Cup qualifiers might have dominated the nation's attention, the scramble for the title and push for survival will continue at the top and bottom of the table.
Leaders, Medeama know the heat is on as they hold a two-point advantage going into their match-day-19 action on Wednesday against Berekum Arsenal.
The Gunners, lying in the relegation zone will attempt to play themselves out of the bottom ranks when they welcome Medeama to the Golden City Park.
The top-liner for the midweek matches will be at the Baba Yara Stadium where Asante Kotoko's title defence faces another stern test in their clash with Berekum Chelsea.
Kotoko, sitting fourth and four points behind the top are aware that failure to collect all three points will affect their title defence.
At the Agyemang Badu Park, Hearts of Oak will be hoping their impressive start to the second round of the competition continues when they meet Aduana Stars.
Wa All Stars have displayed commendable results, winning all three matches in the second round but their outing against Liberty Professionals at the Carl Reindorf Park will be very challenging.
Bashir Hayford is still waiting for his first win in charge of AshantiGold after three matches. The Miners will be at home in a must-win game, the Adansi derby against New Edubiase.
The top-four hopes of Ebusua Dwarfs will continue when they arrive at the Tema Stadium to face Amidaus Professionals.
And to wrap up the midweek fixtures, bottom side, Real Tamale United return to the Tamale Stadium in their first home game since October 2012 following a six-match home ban.
The bottom side, who are winless take on King Faisal.