Contrasting fortunes for the chase for top-four places in midweek opens up the race in the First Capital Plus Premier League which enters match-day-20 this weekend.
Five matches are on the fixture list as Asante Kotoko attempt to bounce back following their derby blues.
One game will come off on Saturday, as bottom side Inter Allies, who boosted their survival hopes after picking a point off AshantiGold at the Len Clay will be determined to get a win against an impressive Liberty Professionals side at the Tema Stadium.
Then on Sunday, four games will be played as the leaders, Kotoko take on rivals AshantiGold in the top-liner at the Baba Yara Stadium.
Kotoko, who have a 12-point lead at the top will be in for another cracker against AshantiGold, who are chasing a first win in their last six matches.
With their last victory in the league coming in December of last year, the Miners will be determined to end their poor run which has seen them slip behind the leaders by 15 points and are on the cusp of dropping out of the top-four.
Heart of Lions returned to winning ways on Wednesday to boost their push for second place but a trip to the Essipon Stadium could prove tough for their ambitions at this stage of the season as they face Hasaacas, who suffered defeat away.
New Edubiase will be at home at the Gyamfi Park to giant-killers, King Faisal, who stopped Kotoko in their tracks.
Second-placed Hearts of Oak with a game in hand take on Amidaus Professionals at the Accra Stadium.
The Phobians have been inconsistent as they sit 12 points behind the top.