Ghana will be without Isaac Vorsah for their opener as the defender is suspended after being shown a red card in qualification.
Vorsah's absence leaves Black Stars coach Goran Stevanovic with 22 players to fall on for the game against newcomers, Botswana on Tuesday at the Stade de Franceville.
Eight players are making their African Cup of Nations debut.
Goalkeepers Adam Kwarasey and Ernest Sowah together with Daniel Opare, Masahudu Alhassan, John Boye, Charles Takyi, Mohammed Abu and Jordan Ayew are all making their tournament debut.