Ghana's only representatives in the CAF Champions League, Berekum Chelsea were handed tough ties against three former champions in Tuesday's draw.
Chelsea, making their competition debut after winning the domestic league last season will take on TP Mazembe, Al Ahly and Zamalek in Group B.
The Berekum side, who have the competition's leading scorer, Emmanuel Clottey in their fold with six goals, must overcome tough tests in the last mini-league of the Champions League to inch closer to the semi-finals.
And they will be traveling to Congo to meet Mazembe and a double trip to Egypt where Ahly and Zamalek are based as they have six group matches lined up.
Chelsea will know not to take their opponents lightly after they qualified for the last 8 at the expense of Raja Casablanca and Coton Sport.
In Group A, holders Esperance are joined by fellow Tunisian side Etoile du Sahel, Sunshine Stars and AS Chlef.
Group A
Esperance Etoile du Sahel Sunshine Stars AS Chlef.
Group B
TP Mazembe Al Ahly Zamalek Berekum Chelsea