Kwesi Appiah makes three changes to the team that started Ghana's previous game for the Group B clash against Mali at the 2013 Africa Cup of Nations.
Isaac Vorsah, Rabiu Mohammed and Harrison Afful make their first starts in this year's competition as the Black Stars go against Mali on Thursday.
Kick off is at 17:00 (15:00GMT) at the Nelson Mandela Bay Stadium in Port Elizabeth.
Ghana line up: Fatau Dauda, John Paintsil, Harrison Afful, John Boye, Isaac Vorsah, Rabiu Mohammed, Albert Adomah, Agyemang Badu, Asamoah Gyan, Mubarak Wakasu, Kwadwo Asamoah