The Black Maidens have beaten their Gambian counterparts 5-1 in their FIFA U-17 Women's World Cup qualifying match played on Bakau, Gambia on Saturday.
Abdulai Mukarama scored four goals after Nina Norshie put Ghana ahead just two minutes into the game.
Fatouma Sowe got the consolation goal for Gambia in the match played at the Independence Stadium in Bakau.
Ghana will host Gambia in the return leg encounter in a fortnight at the Cape Coast Stadium.
Winner of the two-legged tie will face Djibouti in the next stage of the 2018 FIFA World Cup qualifiers for a place in the tournament to be staged in Uruguay from 13 November to 1 December 2018.