Yahaya Mohammed has been ruled out of the 2013 Africa Cup of Nations due to a groin injury.
The Amidaus Professional attacker suffered the recurring injury and has been examined by the Black Stars medical staff.
Yahaya will be out for three-four weeks.
No player will be called to take his place, leaving Kwesi Appiah with a 25-man squad to work with as the Ghana squad depart on Friday for a pre-tournament camp in Abu Dhabi.
Ghana coach Kwesi Appiah said: “It’s a huge blow for the team, especially me. He has been in very good form and I was looking forward to working with him.
“The medical team will follow his recovery and I expect him to get well soon. He will be considered again once he returns to full fitness.”